From the west take US-301 north/US-50 east to exit 45B toward Nesbit Road. Turn right onto Nesbit Road. Take the first left onto Shoreway Drive (three quarters of the way through the circle). The Emergency Center on the left.
From all other points, take US-301 south/US-50 west to exit 45B toward Nesbit Road. Turn left onto Black Beard Road/Winchester Creek Road. Take the first left onto Nesbit Road. Take the second left onto Shoreway Drive (three quarters of the way through the circle). The Emergency Center is on the left.
From the north, take US Route 50 into Cambridge. Turn right on Byrn Street. The hospital is on the right.
From the south, take US Route 50/Ocean Gateway north to Cambridge. Turn left at Maryland Avenue. Take the second right on Aurora Street. Turn left on Byrn Street. The hospital is on the right.
From the north, take US Route 50/Ocean Gateway south. Turn slight right onto MD-322/Easton Bypass/Easton Pkwy. Turn left onto MD-33/Bay Street. Turn right onto North Washington St/MD-565. The hospital is on the right.
From the south, take US Route 50/Ocean Gateway north. Turn left at light onto MD-322/Easton Bypass/Easton Parkway. Turn left onto MD-33/Bay Street. Turn right onto North Washington St/MD-565. The hospital is on the right.